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Background
Numerous patient‐based studies have highlighted the protective role of immunoglobulin E‐mediated allergic diseases on glioblastoma (GBM) susceptibility and prognosis. However, the mechanisms behind this observation remain elusive. Our objective was to establish a preclinical model able to recapitulate this phenomenon and investigate the role of immunity underlying such protection.
Methods...
Marine sediments occupy a significant portion of the Quaternary succession in the West Siberian Arctic but, until recently, their ages and distributions have been strongly debated. Based on new geological, palaeontological and geochronological data obtained within the last decade, we hereby postulate the following: (i) Two different Pleistocene interglacial marine formations are exposed across the...