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Background: Proliferation of vascular smooth muscle cells (VSMC) in the intima of arteries has been viewed as an important mechanism in atherogenesis. Oxidized low-density lipoprotein (oxLDL) can stimulate VSMC growth. Endothelin appears to serve as a mitogen for vascular smooth muscle cells. There is evidence suggesting a role for endothelin and its receptors in atherogenesis.Method: Aortic rabbit...
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