Search results for: T. Werner

Items from 1 to 20 out of 405 results

article

Adolescent exposure to sucrose increases cocaine‐mediated behaviours in adulthood via Smad3

Amy M. Gancarz, Raveena Parmar, Treefa Shwani, Moriah M. Cobb, more

Adolescence, a critical period of developmental period, is marked by neurobiological changes influenced by environmental factors. Here, we show how exposure to sucrose, which is ubiquitously available in modern diets, results in changes in behavioural response to cocaine as an adult. Rats were given daily access to either 10% sucrose or water during the adolescent period (PND28–42). Following this...

article

A role for the endocannabinoid enzymes monoacylglycerol and diacylglycerol lipases in cue‐induced cocaine craving following prolonged abstinence

Swarup Mitra, Pedro H. Gobira, Craig T. Werner, Jennifer A. Martin, more

Addiction Biology > 26 > 5 > n/a - n/a

Following exposure to drugs of abuse, long‐term neuroadaptations underlie persistent risk to relapse. Endocannabinoid signaling has been associated with drug‐induced neuroadaptations, but the role of lipases that mediate endocannabinoid biosynthesis and metabolism in regulating relapse behaviors following prolonged periods of drug abstinence has not been examined. Here, we investigated how pharmacological...

article

mGlu1 tonically regulates levels of calcium‐permeable AMPA receptors in cultured nucleus accumbens neurons through retinoic acid signaling and protein translation

Jessica A. Loweth, Jeremy M. Reimers, Aaron Caccamise, Michael T. Stefanik, more

European Journal of Neuroscience > 50 > 3 > 2590 - 2601

In several brain regions, ongoing metabotropic glutamate receptor 1 (mGlu1) transmission has been shown to tonically suppress synaptic levels of Ca²⁺‐permeable AMPA receptors (CP‐AMPARs) while pharmacological activation of mGlu1 removes CP‐AMPARs from these synapses. Consistent with this, we previously showed in nucleus accumbens (NAc) medium spiny neurons (MSNs) that reduced mGlu1 tone enables and...

article

Backlighting the European Indium Recycling Potentials

Luca Ciacci, Tim T. Werner, Ivano Vassura, Fabrizio Passarini

Journal of Industrial Ecology > 23 > 2 > 426 - 437

With increased understanding of the effects of human activities on the environment and added awareness of the increasing societal value of natural resources, researchers have begun to focus on the characterization of elemental cycles. Indium has captured significant attention due to the potential for supply shortages and nonexistent recycling at end of life. Such a combination of potentially critical...

article

Withdrawal From Cocaine Self-administration Alters the Regulation of Protein Translation in the Nucleus Accumbens

Michael T. Stefanik, Mike Milovanovic, Craig T. Werner, John C.G. Spainhour, more

Biological Psychiatry > 2018 > 84 > 3 > 223-232

Cue-induced cocaine craving incubates during abstinence from cocaine self-administration. Expression of incubation ultimately depends on elevation of homomeric GluA1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors in the nucleus accumbens (NAc). This adaptation requires ongoing protein translation for its maintenance. Aberrant translation is implicated in central nervous system...

article

High rate of persistent iatrogenic atrial septal defect after single transseptal puncture for cryoballoon pulmonary vein isolation

Markus Linhart, Jessica T. Werner, Florian Stöckigt, Annika T. Kohlmann, more

Journal of Interventional Cardiac Electrophysiology > 2018 > 52 > 2 > 141-148

Purpose Congenital atrial septal defect (ASD) is associated with increased morbidity, whereas little is known about the rate of spontaneous closure, associated clinical and echocardiographic parameters, or complications of iatrogenic atrial septal defect (iASD) beyond 1 year of follow-up. Persistent iASD after transseptal puncture for PVI has been described in up to 38% of small cohorts of patients...

article

Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence

Ramesh Chandra, Michel Engeln, Christopher Schiefer, Mary H. Patton, more

Neuron > 2017 > 96 > 6 > 1327-1341.e6

Altered brain energy homeostasis is a key adaptation occurring in the cocaine-addicted brain, but the effect of cocaine on the fundamental source of energy, mitochondria, is unknown. We demonstrate an increase of dynamin-related protein-1 (Drp1), the mitochondrial fission mediator, in nucleus accumbens (NAc) after repeated cocaine exposure and in cocaine-dependent individuals. Mdivi-1, a demonstrated...

article

Electronic implementation of a practical matched filter for a chaos-based communication system

Frank T. Werner, Benjamin K. Rhea, R. Chase Harrison, Robert N. Dean

Chaos, Solitons & Fractals > 2017 > 104 > C > 461-467

Presented is an electronic implementation of a matched filter intended for chaos-based communication systems. While implementing the transmitter side of such systems is relatively trivial, the receiver has proven challenging to develop. Most chaotic systems lack a known fixed basis function, making it difficult to develop a matched filter for them. Instead, their receivers rely on more complicated...

article

Verwendung der Nahinfrarotspektroskopie zur Kontrolle der Extremitätenperfusion unter venoarterieller ECMO-Therapie

T. Werner, D. Lunz, A. Philipp, B. Flörchinger, more

Der Anaesthesist > 2017 > 66 > 11 > 862-866

Patienten unter peripherer venoarterieller extrakorporaler Membranoxygenierung haben ein hohes Risiko, eine Ischämie der unteren Extremität zu erleiden. Im Allgemeinen erfolgt die regelmäßige Kontrolle anhand klinischer und laborchemischer Parameter, um Komplikationen schnell erkennen und beheben zu können. Diese Kontrollen sind aufgrund von Schockzuständen, nichtpulsatilem Fluss und Vasopressortherapie...

article

Efficacy of guanfacine extended release in children and adolescents with ADHD and comorbid oppositional defiant disorder

M. Huss, J. Newcorn, D. Connor, A. Hervás, more

European Neuropsychopharmacology > 2017 > 27 > S4 > S1114

article

The Sequencing of Adjuvant Chemotherapy and Radiation in Endometrial Cancer and the Associated Impact on Survival

D. Boothe, A. Orton, J. Kim, T. Werner, more

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > E283-E284

article

The Prognostic Value of Lymphovascular Space Invasion in Locoregional Endometrial Cancer by Adjuvant Treatment and Stage

D. Boothe, S. Francis, T. Werner, A.H. Wolfson, more

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > E284

article

Corrigendum to “The world's lead–zinc mineral resources: Scarcity, data, issues and opportunities” [Ore Geol. Rev. 80 (2017) 1160–1190]

Gavin M. Mudd, Simon M. Jowitt, Timothy T. Werner

Ore Geology Reviews > 2017 > 89 > C > 1131

article

Characterising a PCB electrical conductivity sensor using electromagnetic simulation and a genetic algorithm

Frank T. Werner, Robert N. Dean

IET Science, Measurement & Technology > 2017 > 11 > 6 > 761 - 765

Measuring electrical conductivity makes it possible to determine the concentration of dissolved ionic compounds in the water. Presented is a sensor developed for easily measuring the electrical conductivity of aqueous solutions. This sensor is comprised of two planar electrodes integrated onto a printed circuit board (PCB). PCB technology enables this sensor to be manufactured at high volumes for...

article

Unresolved Complexity in Assessments of Mineral Resource Depletion and Availability

Stephen A. Northey, Gavin M. Mudd, T. T. Werner

Natural Resources Research > 2018 > 27 > 2 > 241-255

Considerations of mineral resource availability and depletion form part of a diverse array of sustainable development-oriented studies, across domains such as resource criticality, life cycle assessment and material flow analysis. Given the multidisciplinary nature of these studies, it is important that a common understanding of the complexity and nuances of mineral supply chains be developed. In...

article

Criteria for failure and worsening after surgery for lumbar disc herniation: a multicenter observational study based on data from the Norwegian Registry for Spine Surgery

David A. T. Werner, Margreth Grotle, Sasha Gulati, Ivar M. Austevoll, more

European Spine Journal > 2017 > 26 > 10 > 2650-2659

Purpose In clinical decision-making, it is crucial to discuss the probability of adverse outcomes with the patient. A large proportion of the outcomes are difficult to classify as either failure or success. Consequently, cutoff values in patient-reported outcome measures (PROMs) for “failure” and “worsening” are likely to be different from those of “non-success”. The aim of this study was to identify...

article

The world's by-product and critical metal resources part I: Uncertainties, current reporting practices, implications and grounds for optimism

Gavin M. Mudd, Simon M. Jowitt, Timothy T. Werner

Ore Geology Reviews > 2017 > 86 > C > 924-938

Many of the metals extracted as by-products and rated as ‘critical’ are vital to important modern technologies but are seldom reported as extractable commodities by the mining industry. This creates numerous uncertainties and challenges in estimating the global resources of these metals; here we outline the current approaches (or lack thereof) used in resource reporting and identify and discuss the...

article

The exposure of global base metal resources to water criticality, scarcity and climate change

Stephen A. Northey, Gavin M. Mudd, Timothy T. Werner, Simon M. Jowitt, more

Global Environmental Change > 2017 > 44 > C > 109-124

Mining operations are vital to sustaining our modern way of life and are often located in areas that have limited water supplies or are at an increased risk of the effects of climate change. However, few studies have considered the interactions between the mining industry and water resources on a global scale. These interactions are often complex and site specific, and so an understanding of the local...

article

The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries

Sarah C. Hsu, Thomas G. Gilgenast, Caroline R. Bartman, Christopher R. Edwards, more

Molecular Cell > 2017 > 66 > 1 > 102-116.e7

Bromodomain and extraterminal motif (BET) proteins are pharmacologic targets for the treatment of diverse diseases, yet the roles of individual BET family members remain unclear. We find that BRD2, but not BRD4, co-localizes with the architectural/insulator protein CCCTC-binding factor (CTCF) genome-wide. CTCF recruits BRD2 to co-bound sites whereas BRD2 is dispensable for CTCF occupancy. Disruption...

article

Trafficking of calcium-permeable and calcium-impermeable AMPA receptors in nucleus accumbens medium spiny neurons co-cultured with prefrontal cortex neurons

Craig T. Werner, Conor H. Murray, Jeremy M. Reimers, Niravkumar M. Chauhan, more

Neuropharmacology > 2017 > 116 > C > 224-232

AMPA receptor (AMPAR) transmission onto medium spiny neurons (MSNs) of the adult rat nucleus accumbens (NAc) is normally dominated by GluA2-containing, Ca²⁺-impermeable AMPAR (CI-AMPARs). However, GluA2-lacking, Ca²⁺-permeable AMPA receptors (CP-AMPARs) accumulate after prolonged withdrawal from extended-access cocaine self-administration and thereafter their activation is required for the intensified...

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INFONA - science communication portal

Search results for: T. Werner

Adolescent exposure to sucrose increases cocaine‐mediated behaviours in adulthood via Smad3

A role for the endocannabinoid enzymes monoacylglycerol and diacylglycerol lipases in cue‐induced cocaine craving following prolonged abstinence

mGlu1 tonically regulates levels of calcium‐permeable AMPA receptors in cultured nucleus accumbens neurons through retinoic acid signaling and protein translation

Backlighting the European Indium Recycling Potentials

Withdrawal From Cocaine Self-administration Alters the Regulation of Protein Translation in the Nucleus Accumbens

High rate of persistent iatrogenic atrial septal defect after single transseptal puncture for cryoballoon pulmonary vein isolation

Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence

Electronic implementation of a practical matched filter for a chaos-based communication system

Verwendung der Nahinfrarotspektroskopie zur Kontrolle der Extremitätenperfusion unter venoarterieller ECMO-Therapie

Efficacy of guanfacine extended release in children and adolescents with ADHD and comorbid oppositional defiant disorder

The Sequencing of Adjuvant Chemotherapy and Radiation in Endometrial Cancer and the Associated Impact on Survival

The Prognostic Value of Lymphovascular Space Invasion in Locoregional Endometrial Cancer by Adjuvant Treatment and Stage

Corrigendum to “The world's lead–zinc mineral resources: Scarcity, data, issues and opportunities” [Ore Geol. Rev. 80 (2017) 1160–1190]

Characterising a PCB electrical conductivity sensor using electromagnetic simulation and a genetic algorithm

Unresolved Complexity in Assessments of Mineral Resource Depletion and Availability

Criteria for failure and worsening after surgery for lumbar disc herniation: a multicenter observational study based on data from the Norwegian Registry for Spine Surgery

The world's by-product and critical metal resources part I: Uncertainties, current reporting practices, implications and grounds for optimism

The exposure of global base metal resources to water criticality, scarcity and climate change

The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries

Trafficking of calcium-permeable and calcium-impermeable AMPA receptors in nucleus accumbens medium spiny neurons co-cultured with prefrontal cortex neurons

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