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Male F344 rats exposed to bromodichloromethane (BDCM) by gavage at 50 or 100mg/kg/day for 5days a week for 28days excreted large amounts of formic acid in their urine, which was accompanied by a change in urinary pH. Male B6C3F1 mice exposed to BDCM at 25 or 50mg/kg/day for 5days a week for 28days also excreted increased amounts of formic acid in their urine. In rats, formate excretion was dose and...
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