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Growth factors play a crucial role in regulating a broad variety of biological processes and are regarded as powerful therapeutic agents in tissue engineering and regenerative medicine in the past decades. However, their application is limited by their short half‐lives and potential side effects in physiological environments. Hydrogels are identified as having the promising potential to prolong the...
As part of our ongoing effort to develop a biodegradable nerve guidance channel based on chitin/chitosan, we conducted a systematic in vitro study on the biodegradation and neural cell compatibility of chitosan and N-acetylated chitosan. The in vitro degradation (pH 7.4, 37°C) in the presence of 1.5μg/ml lysozyme showed a progressive mass loss to greater than 50% within 4 weeks for films with 30–70%...
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