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Background
Combining photon or proton radiotherapy with targeted therapy shows promise for head and neck cancer (HNSCC). The poly (adenosine diphosphate [ADP]‐ribose) polymerase‐1/2 inhibitor niraparib targets DNA damage repair (DDR). We evaluated the effects of niraparib in combination with photons or protons, and its effects on the relative biological effectiveness (RBE) of protons, in human HNSCC...
Background
Human papillomavirus (HPV)‐positive oropharyngeal carcinomas response better to X‐ray therapy (XRT) than HPV‐negative disease. Whether HPV status influences the sensitivity of head and neck cancer cells to proton therapy or the relative biological effectiveness (RBE) of protons versus XRT is unknown.
Methods
Clonogenic survival was used to calculate the RBE; immunocytochemical analysis...
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