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Antibiotika Eine Gold‐Nanoschicht bindet an Lipopolysaccharid (LPS) und verhindert so die Bindung von Colistin an freies LPS. Wie S. Y. Lin et al. in ihrer Zuschrift auf S. 1446 schildern, steigt dadurch die antibakterielle Wirkung von Colistin, das nun in geringeren Dosen eingesetzt werden kann.
A strong interaction between colistin, a last‐resort antibiotic of the polymyxin family, and free lipopolysaccharide (LPS, also referred to as endotoxin), released from the Gram‐negative bacterial (GNB) outer membrane (OM), has been identified that can decrease the antibacterial efficacy of colistin, potentially increasing the dose of this antibiotic required for treatment. The competition between...
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