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Improving the precise accumulation and retention of nanomedicines in tumor cells is one of the keys to effective therapy of tumors. Herein, supramolecular peptides capped Au nanocages (AuNCs) that may self‐aggregate into micron‐sized clusters intracellularly in response to spermine (SPM), leading to specific accumulation and retention of AuNCs in SPM‐overexpressed tumor cells, are developed. In this...
Breast Cancer Therapy
In article number 2201971, Ruibing Wang and co‐workers develop supramolecular peptide (based upon the host–guest interaction between cucurbit[7]uril and Phe‐Phe‐Val‐Leu‐Lys) capped Au nanocages, to allow self‐aggregation into micron‐sized clusters inside spermine‐overexpressed tumor cells, leading to specific accumulation and retention of Au nanocages in breast tumor for synergistic...
Nowadays, destruction of redox homeostasis to induce cancer cell death is an emerging anti‐cancer strategy. Here, the authors utilized pH‐sensitive acetalated β‐cyclodextrin (Ac‐β‐CD) to efficiently deliver dihydroartemisinin (DHA) for tumor ferroptosis therapy and chemodynamic therapy in a synergistic manner. The Ac‐β‐CD‐DHA based nanoparticles are coated by an iron‐containing polyphenol network...
Inorganic nanomedicine has attracted increasing attentions in biomedical sciences due to their excellent biocompatibility and tunable, versatile functionality. However, the relatively poor accumulation and retention of these nanomedicines in targeted tissues have often hindered their clinical translation. Herein, highly efficient, targeted delivery, and in situ aggregation of ferrocene (Fc)‐capped...
The precise accumulation and extended retention of nanomedicines in the tumor tissue has been highly desired for cancer therapy. Here a novel supramolecular‐peptide derived nanodrug (SPN) that can be transformed to microfibers in response to intracellular polyamine in cancer cells for significantly enhanced tumor specific accumulation and retention is developed. The supramolecular‐peptide is constructed...
Gas therapy has emerged as a new therapeutic strategy in combating cancer owing to its high therapeutic efficacy and biosafety. However, the clinical translation of gas therapy remains challenging due to the rapid diffusion and limited tissue penetration of therapeutic gases. Herein, a self‐propelled, asymmetrical Au@MnO2 nanomotor for efficient delivery of therapeutic gas to deep‐seated cancer tissue...