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We have recently found a novel retinoid, 6-[3-(1-adamantyl)-4-hydroxphenyl]-2-naphthalenecarboxylic acid (CD437), which induces G 1 cell cycle arrest and apoptosis in human breast carcinoma (HBC) cells (Oncogene11, 493–504, 1995). CD437 downregulates the expression of a number of proteins which antagonize apoptosis. bcl-X L , a homologue of bcl-2, antagonizes apoptosis, while bcl-X...
Thyroid hormone (T 3 ) and estradiol (Est) modulate biological processes by binding to nuclear receptor proteins that, through interactions with specific response elements in the regulatory regions of genes, modulate gene transcription. Est stimulation of estrogen receptor (ER)-positive breast carcinoma cell growth occurs through its ability to bind to the ER and activate gene transcription...
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