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The liver maintains an immunologically tolerant environment as a result of continuous exposure to food and bacterial constituents from the digestive tract. Hepatotropic pathogens can take advantage of this niche and establish lifelong chronic infections causing hepatic fibrosis and hepatocellular carcinoma. Macrophages (Mϕ) play a critical role in regulation of immune responses to hepatic infection...
Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma. Here we report that infection of hepatic cells by HCV stimulates nuclear factor kappa B (NFκB)‐dependent production of thymic stromal lymphopoietin (TSLP). Hepatocyte‐derived TSLP in turn conditions dendritic cells (DCs) to drive T‐helper (Th)17 differentiation. The TSLP secreted by HCV‐infected hepatoma cells...
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