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Characteristic differences of prions may account for the conformational diversity of the pathogenic isoform of prion protein (PrP Sc ). Here, we applied a protein detection procedure by using fluorescent-labelled peptides for detecting PrP Sc . Five prion protein (PrP) related peptides were found to change significantly their fluorescent intensities with prion-affected animal samples...
We recently established mouse microglial cells persistently infected with mouse-adapted scrapie ME7 (ScMG20/ME7) for in vitro study of prion pathogenesis. Here, we found that ScMG20/ME7 cells were hypersensitive to P2X7 receptor agonists, as demonstrated by sustained Ca 2+ influx, membrane pore formation, cell death, and interleukin-1β release. P2X7 mRNA expression was upregulated in these...
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