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To explore new platform for DNA intercalation and potent antitumor agent, a series of 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxylic acid esters chromophores has been studied. Their intercalation geometries with DNA were revealed through absorption titration, SYBR Green-DNA melt curve, circular dichroism(CD), and docking studies. It was identified that some of the compounds could intercalate into...
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