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The architecture of DNA is not exclusively assembled with a sequence of Watson–Crick guanine–cytosine (GC) and adenine–thymine (AT) base pairs. On the contrary, recent experiments have detected G-quadruplex structures in G-islands, whereas C-rich regions are organized as intercalated motif (i-motif) structures. In the latter, several hemiprotonated–cytosine dimers are inserted in a large repetitive...
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