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Lysine-rich phosphorylated cystatin α (P-cystatin α) from newborn rat epidermis is a good substrate for epidermal transglutaminase (TGase) and also one of the component proteins of cornified envelope in the stratum corneum. Since the filaggrin linker segment peptide was efficiently conjugated with P-cystatin α and was mediated by epidermal TGase in the presence of Ca 2+ ions, filaggrin...
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