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Mesenchymal Stem Cells
In article number 2301748, Peiyan Yuan, Songtao Shi, Xiaoxing Kou, and co‐workers establish a naturally occurring apoptotic encapsulation system in apoptotic mesenchymal stem cells to efficiently generate stable nanodrug‐apoVs capable of improving multiple myeloma treatment in mice.
Extracellular vesicles (EVs) are lipid bilayer nanovesicles released from living or apoptotic cells that can transport DNA, RNA, protein, and lipid cargo. EVs play critical roles in cell–cell communication and tissue homeostasis, and have numerous therapeutic uses including serving as carriers for nanodrug delivery. There are multiple ways to load EVs with nanodrugs, such as electroporation, extrusion,...