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We developed a portable odorant detection system composed of collagen micro-pillars with cells expressing olfactory receptors and a CMOS imaging sensor; the CMOS imaging sensor caught fluorescence signals of Ca2+ increased by odorant molecules. While low sensitiveness of the CMOS imaging sensor was insufficient to detect the fluorescent signal from a single cell, the odorant detection system achieved...
We develop a device adapted for repetitive formation of horizontal lipid bilayer membranes. This device allows simultaneous optical and electrophysiological measurements of the formed membranes. We integrated a rotational chamber on a fluidic channel separated by a parylene micropore. The rotational motion is designed to form a bilayer repeatedly. This rotational process emulates the conventional...
This paper presents a new method to fabricate 2-dimensional collagen sheets whose internal molecular structures form highly-aligned nanofibers in one direction. In this work, collagen nanofibers are self-aligned in fully 2-dimensional substrates by applying cyclic stretch during the gelation process of collagen solution, and the fabricated collagen sheets induce the alignment of cells without any...
This paper describes the preparation of a cell-sized vesicle containing small vesicles from a two-planar lipid bilayer in a triple-well device using a pulsed jet flow. First, the size distribution of the cell-sized vesicles is estimated using a double-well device wherein a separator having a hole diameter of 100, 200, or 500 μm is mounted between the wells. Moreover, the small vesicles are successfully...
This paper describes a preliminary report of microfabricated dissolvable mobile microplates for handling adherent cells. We fabricated micron-sized (10∼100 μm) alginate hydrogel plates by soft lithography, attached adherent cells, and handled them. In contrast to previous microplates [1–3], the alginate microplates could be dissolved without damaging cells. We demonstrated dissolution of microplates...
This paper describes the formation of a micro-scale gel strand constructed with self-assembled supramolecular nanofibers fabricated in a microfluidic channel. The supramolecular nanofibers are highly aligned along the axis of the gel strand; this morphology is very different from the bulk gel. Moreover, we found that small molecules are able to diffuse along the supramolecular-nanofiber's axis. We...
This paper describes a method to transplant neurospheroid network onto the rat brain. We first patterned the uniform sized neurospheroids on the PDMS microchamber, and cultured for 1-2 weeks. After 2-week culture, the neurospheroids tightly connected each other with extending their neuronal processes (e.g. dendrite, axons) and formed neuronal network. We realized that the neurospheroid network can...
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