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We report a method to measure contractile forces of cardiomyocytes at cellular level using microplates; pairs of single-cell sized plates are connected by a flexible hinge at the center. Cardiomyocytes repeatedly contract and relax, and thereby fold and stretch the microplates at the flexible hinge. By measuring the change of the bending angle in folded microplates, we can estimate contractile forces...
This paper presents a new method to fabricate 2-dimensional collagen sheets whose internal molecular structures form highly-aligned nanofibers in one direction. In this work, collagen nanofibers are self-aligned in fully 2-dimensional substrates by applying cyclic stretch during the gelation process of collagen solution, and the fabricated collagen sheets induce the alignment of cells without any...
We propose a method for constructing fiber-type three-dimensional (3D) tissue of human iPS-derived cardiomyocytes and quantifying its contractile force in response to the addition of drug. By culturing the cardiomyocytes in micropatterned hydrogel with anchors, we succeeded in fabrication of the fibers with aligned cardiomyocytes and fixation of the fiber edges to the anchors. Since the fiber generated...
Microenvironmental biophysical stimuli influence diverse cellular functions, such as directional motility and stem cell differentiation. Previously, researchers have tuned the linear stiffness of microposts to investigate cell mechanobiological processes and direct cellular behavior; however, microposts suffer from an inherent, yet critical drawback — regulation of micropost stiffness is fundamentally...
This paper describes a contactless manipulation system for giant liposomes in an aqueous flow by negative dielectrophoresis (nDEP). The system consists of 2 pairs of comb electrodes that face each other across a perpendicular channel. This design allows an nDEP force to be focused at the center of the gap of the electrodes and the liposomes to align in lines without contacting either the electrodes...
This work presents a strategy that realizes efficient incorporation of membrane proteins in liposomes into a planar bilayer lipid membrane by using dielectrophoretic (DEP) force. The device consists of a chamber and a channel separated by a ??m-sized aperture that suspends a planar bilayer membrane. Applying an AC electric field across the membrane, the DEP force concentrates at the bilayer area therefore...
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