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A rapid and high-resolution bioprinter based on a capillary coaxial microfluidic printer head and vacuum substrate, was conceived and built up in this work. We demonstrate the printing of porous (400 μm pitch) 3D bio-scaffolds made from calcium alginate microfibers with a printing resolution (i.e. fiber diameter) of ca. 150 microns, at a speed of 40 mm/s, which is approximately 10x faster than existing...
This study reports on a novel concept for silicon (Si)-based intracortical neural probes with improved mechanical flexibility and reduced dimensions. Microelectrode arrays with cross-sections as small as 50 × 120 µm2 and polyimide ribbon cables of similar width but a thickness of only 11 µm are assembled into slender, flexible recording systems. As their interfacing section is reduced to the width...
This paper describes a method to arrange liposomes into organized structures with biochemical binding of streptavidin-biotin complex, inspired by the biological anchoring junction. This approach enhances the stability of the liposome structure, which would provide an improved model for a liposome-based tissue in synthetic biology.
This paper presents a new method to fabricate 2-dimensional collagen sheets whose internal molecular structures form highly-aligned nanofibers in one direction. In this work, collagen nanofibers are self-aligned in fully 2-dimensional substrates by applying cyclic stretch during the gelation process of collagen solution, and the fabricated collagen sheets induce the alignment of cells without any...
We propose a method for constructing fiber-type three-dimensional (3D) tissue of human iPS-derived cardiomyocytes and quantifying its contractile force in response to the addition of drug. By culturing the cardiomyocytes in micropatterned hydrogel with anchors, we succeeded in fabrication of the fibers with aligned cardiomyocytes and fixation of the fiber edges to the anchors. Since the fiber generated...
This paper introduces a new technique for patterning functionalization layers on substrates with high-topography. The method is based on a parylene-C template shaped by a structured, sacrificial photoresist layer and attached to the substrate where functionalization is not intended. After photoresist removal and surface functionalization, the parylene layer is peeled off, leaving all areas initially...
This paper aimed to develop a pendant liposome system that allows the access to both internal and external solutions of the formed liposomes. The access to the internal solution was achieved by a through-hole fabricated on the substrate, which was designed underneath the pendant-like, dome-shaped liposome. The formation of a uniform-size liposome array was based on our previous works that applied...
Microenvironmental biophysical stimuli influence diverse cellular functions, such as directional motility and stem cell differentiation. Previously, researchers have tuned the linear stiffness of microposts to investigate cell mechanobiological processes and direct cellular behavior; however, microposts suffer from an inherent, yet critical drawback — regulation of micropost stiffness is fundamentally...
This paper describes a contactless manipulation system for giant liposomes in an aqueous flow by negative dielectrophoresis (nDEP). The system consists of 2 pairs of comb electrodes that face each other across a perpendicular channel. This design allows an nDEP force to be focused at the center of the gap of the electrodes and the liposomes to align in lines without contacting either the electrodes...
We aimed to create a method in micropatterning of different kinds of biomaterials as a platform of a molecular communication system onto a single substrate. This paper proposes a multiple poly(para-xylylene) (parylene) simultaneous peel-off process and demonstrates that different kinds of proteins and DNAs were successfully microarrayed onto the single substrate. Further, the functionalities and the...
This paper describes a methodology that realizes uniformly-sized liposome arrays with gentle hydration. The system consists of a dried lipid pattern on a substrate that is a micropatterned polymer thin film on an indium-tin-oxide (ITO) glass slide. An electrospray deposition (ESD) method was applied to obtain the lipid patterning at the polymer pattern where the ITO surface was exposed. With a simple...
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