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Disturbances of sleep–wake rhythms are an important problem in Alzheimer's disease (AD). Circadian rhythms are regulated by clock genes. Transforming growth factor‐beta (TGF‐β) is overexpressed in neurons in AD and is the only cytokine that is increased in cerebrospinal fluid (CSF). Our data show that TGF‐β2 inhibits the expression of the clock genes Period (Per)1, Per2, and Rev‐erbα, and of the clock‐controlled...
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