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Mehr als die Summe der Teile: Neuartige Hybridsubstanzen bestehen aus einem organischen, β‐Faltblatt‐brechenden Teil und einem die Zielsubstanz (Aβ) erkennenden, D‐enantiomeren Peptidteil (siehe Bild). Die Substanzen wurden chemisch synthetisiert und mit verschiedenen Techniken charakterisiert. Sie vereinen rationales Design mit Substanzselektion aus Bibliotheken und inhibieren die Aβ‐Oligomeraggregation...
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