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The non-therapeutic cisplatin congeners transplatin and chloroethylenetriamine platinum (dien) inhibited translation to a similar extent as cisplatin did. The ic 50 values were: cisplatin 23 μM, transplatin 54 μM, and dien 117 μM. Unlike certain heavy metal inhibitors of translation, the effect of neither cisplatin nor the congeners was reversed by 3 :5 -cyclic adenosine monophosphate...
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