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The effects of aldose reductase inhibitors on lens protein modifications induced by naphthalene-1,2-dihydrodiol were investigated in vitro to confirm the role of aldose reductase on naphthalene cataract formation. HPLC analysis of naphthalene-1,2-dihydrodiol incubated with aldose reductase and NAD + indicated the formation of a metabolite peak corresponding to 1,2-naphthoquinone. Soluble proteins...
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