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In this paper, we develop a new method for prediction O-linked glycosylation site and pattern analysis in protein, which combines independent component analysis (ICA) with a multi-layer neural network (NN). ICA is first used to construct main basis (subspace) of the protein sequence for features extraction. The projections of protein sequence on the subspace with low dimension are used as input data...
Glycosylation is one of the common post-translation modification of protein in eukaryotic cells. Conventional neural network methods have been applied to predict glycosylation sites in protein sequence and the prediction accuracy is dependent on the dimension of feature vector (length of protein sequence). Though the prediction accuracy can be improved by increasing the length of protein sequence,...
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