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Recent development of MeRIP-Seq enabled the global unbiased profiling of transcriptome-wide N6-Adenosine. With this technique, it is now possible to detect the RNA methylation sites under a specific condition or the differential methylation sites between two experimental conditions. However, as an affinity-based approach, MeRIP-Seq has yet provided base-pair resolution. A single methylation site reported...
The study of mRNA methylation is an emerging research field greatly fueled by recent advancement in high throughput sequencing technology. We propose here a binomial likelihood ratio test ("bltest") aiming at detecting differentially methylated mRNA with MeRIP-Seq data, "bltest" models the read counts of each RNA methylation site in IP and input samples with a binomial distribution...
Muscle forces modeling and computation around the elbow are focused on in this paper when the elbow flexing and extending in the sagittal plane. The paper introduces a Rehabilitation Intelligent Training System (RITS) for restoration of motor function. The system has advantages of small size, less weight and interaction during the rehabilitation process. Furthermore, this system mainly consists of...
This paper reports a switchable metamaterial working at terahertz (THz) regime, which is realized by using MEMS fabrications. The resonance induced by 2.60-THz incidence is switched by reconfiguring the metamaterial element, which is analyzed using the coupled oscillators model. The resonance switching of the metamaterial has potential applications, such as optical switching, tunable filtering, THz...
Cloud computing is the latest technology trend in delivering computing resources as a service. In practice, cloud service providers tend to offer services that can be grouped into three categories: software as a service (Saas), platform as a service (Paas) and infrastructure as a service (Iaas). Iaas is the delivery of hardware (server, storage and network) as a service. Cloud computing moves computations...
Protein secondary structure prediction is one of the most important and challenging problems in structural bioinformatics, which has been an essential task in determining the structure and function of the proteins. Despite significant progress made in recent years, protein structure prediction maintains its status as one of the prime unsolved problems in computational biology. A novel probability...
Comparative analysis of protein interaction networks plays a key role in the study of evolution and molecular etiology of diseases. A topology-based method is proposed in this paper to search biologically significant sub networks in protein interaction networks with relatively high accuracy. Different with other methods, the present method takes into account incorrectness and incompleteness of biological...
A vast number of Protein-Protein Interactions (PPIs) databases and different data formats among them make it difficult for researchers to research PPIs efficiently. We propose the Integrated Query Database (IQD) and Hot-Spot Database (HSD) on CPSE-Bio (PSE-Bio based on Cloud computing) to solve this problem in this paper. The IQD integrates several PPIs databases and researchers can retrieve PPIs...
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