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Protein-RNA interactions are vitally important to a number of fundamental cellular processes, including regulation of gene expression such as RNA splicing, transport and translation, protein synthesis and assembly of ribosome. More detailed information on the Protein-RNA interaction is helpful for comprehending the function notation and molecular regulatory mechanism, meanwhile, knowing the knowledge...
Determination of protein structural class is a quite meaningful topic in protein science, because a priori knowledge of a protein structural class can provide useful information about its overall structure. The results of most previous studies used high homologous dataset with four structural classes should not be perceived as reliable, because the sequence homology has very significant impact on...
Evolutionary conservation estimated from a multiple sequence alignment is a powerful indicator of the functional significance of a residue, and helps to predict active sites, ligand binding sites, and protein interaction interfaces. Many algorithms that calculate conservation work well provided better and balanced alignment are used. Such a strong dependence on the alignment makes the results highly...
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