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BACKGROUND
Commercial compound databases represent rich sources of potential starting points for pharmaceutical and agrochemical product development. Routine insecticidal screening of compounds ordered from these sources led to the identification of a 3‐aminopyridyl urea with activity against Myzus persicae (Sulzer) (green peach aphid). Based on this activity and its structural novelty, further exploration...
BACKGROUND
We hypothesized that the exploration of chemical space around compounds with reported insecticidal activity could be a viable strategy for discovering novel, insecticidally active areas of chemistry.
RESULTS
A series of thioureas and isothioureas were prepared as part of a scaffold‐hopping effort around known insecticidal compounds. Many of these compounds showed excellent activity against...
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