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We evaluated the sensation of dyspnea induced by hypercapnia alone and a combination of hypercapnia and flow-resistive loading by the use of visual analogue scale (VAS) and the use of 13 listed descriptors in 23 healthy subjects. Hypercapnia alone caused a modest degree of dyspnea characterized by both air hunger and work/effort sensations. An addition of inspiratory flow-resistive loading (IRL) caused...
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