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Background
Environmental enrichment (EE) has been shown to enhance cognitive function in mouse models of Alzheimer's disease (AD). Magnesium‐L‐threonate (MgT) is a compound with a newly discovered effect to rescue learning and memory function in aging and AD mice.
Aim
To study the additive therapeutic effect of EE combined with MgT (EM) and the potential mechanism underlying the effects.
Materials...
AimsThis study investigated the neuroprotective properties of icariin (an effective component of traditional Chinese herbal medicine Epimedium) on neuronal function and brain energy metabolism maintenance in a triple‐transgenic mouse model of Alzheimer's disease (3 × Tg‐AD).
Methods3 × Tg‐AD mice as well as primary neurons were subjected to icariin treatment. Morris water maze assay, magnetic resonance...
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