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Transcription factor NF-κB plays a key role for the inducible expression of genes mediating proinflammatory effects and is thus an important target for the development of antiinflammatory drugs. Here, we show that extracts from the plant Plagius flosculosus (L.) Alavi and Heyw. can inhibit the induction of NF-κB activity, and we describe the identification of three spiroketal compounds. Of those,...
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