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Background and Aims
Longitudinal electronic health record (EHR) data offer a large‐scale, untapped source of phenotypical information on harmful alcohol use. Using established, alcohol‐associated variants in the gene that encodes the enzyme alcohol dehydrogenase 1B (ADH1B) as criterion standards, we compared the individual and combined validity of three longitudinal EHR‐based phenotypes of harmful...
BackgroundWe conducted a genomewide association study (GWAS) for maximum number of alcoholic drinks consumed in a 24‐hour period (“MaxDrinks”), in 2 independent samples comprised of over 9,500 subjects, following up on our GWAS for alcohol dependence (AD) in European Americans (EAs) and African Americans (AAs).
MethodsThe samples included our GWAS samples (Yale‐UPenn) recruited for studies of the...
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