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YM155, a small-molecule survivin suppressant, specifically binds to the transcription factor ILF3, which regulates the expression of survivin [1]. In this experiment we have demonstrated that p54 nrb binds to the survivin promoter and regulates survivin expression. p54 nrb forms a complex with ILF3, which directly binds to YM155. YM155 induces disruption of the ILF3/p54 nrb ...
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