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Measuring input-output relations of single neurons in awake animals is essential for understanding how information is processed in the brain. So far, the most complete input-output relations were measured in brain slices. However, brain slices lack physiological input to dendrites and soma. Here we describe a method that combines two-photon microscopy and electrophysiology to simultaneously measure...
How does an animal in a steady environment self-initiate various behaviors? Results in this study suggest that the complex dynamic of spontaneous behavior in mice was highly deterministic. By temporally correlating three basic neuronal network properties, we can predict many minutes of spontaneous behavior. This description and prediction of neuronal activity and behavior may refine our knowledge...
Model-based decision making requires prediction of future states by action-dependent state transition models. To investigate their neural implementation, mice were trained to do an auditory virtual navigation task and neuronal activity was recorded in the posterior parietal cortex (PPC) and the posteromedial cortex (PM), with the genetically encoded calcium indicator GCaMP6f after gene transfer by...
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