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These studies examined the in vivo pharmacokinetics and efficacy of five anti-methamphetamine monoclonal antibodies (mAbs, K D values from 11 to 250nM) in rats. While no substantive differences in mAb systemic clearance (t 1/2 =6.1–6.9 days) were found, in vivo function was significantly reduced within 1–3 days for four of the five mAbs. Only mAb4G9 was capable of prolonged efficacy,...
Our studies examined pharmacokinetic mechanisms involved in high-affinity (K d ~11 nM) monoclonal antibody-based antagonism of (+)-methamphetamine-induced locomotor effects. Male rats received (+)-methamphetamine (0.3, 1, or 3 mg/kg i.v.) followed 30 min later by saline or anti-(+)-methamphetamine monoclonal antibody. All groups received a constant dose of monoclonal antibody that was equimolar...
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