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In our continuing search for novel small‐molecule anticancer agents, we designed and synthesized a series of novel (E)‐N'‐(3‐allyl‐2‐hydroxy)benzylidene‐2‐(4‐oxoquinazolin‐3(4H)‐yl)acetohydrazides (5), focusing on the modification of substitution in the quinazolin‐4(3H)‐one moiety. The biological evaluation showed that all 13 designed and synthesized compounds displayed significant cytotoxicity against...
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