Wyniki wyszukiwania dla: Etsuo Niki

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Oxidative stress and antioxidants: Distress or eustress?

Etsuo Niki

Free Radical Biology and Medicine > 2018 > 124 > C > 564

Oxidative stress, a signal which affects redox balance and induces oxidative modification of biological molecules, may have multiple faces. Reactive oxygen and related species (ROS) protect us from invading xenobiotics and act as physiological redox signaling messenger. The production of ROS is tightly regulated and the reactions are selective. On the other hand, ROS produced by unregulated manner...

artykuł

Antioxidant action of fermented grain food supplement: Scavenging of peroxyl radicals and inhibition of plasma lipid oxidation induced by multiple oxidants

Mayuko Morita, Yuji Naito, Etsuo Niki, Toshikazu Yoshikawa

Food Chemistry > 2017 > 237 > C > 574-580

Unregulated oxidative modification of biological molecules induced by multiple oxidants in vivo has been implicated in the pathogenesis of various diseases. Accordingly, the role of antioxidants contained in foods in the maintenance of health and prevention of diseases has received much attention. The efficacy of antioxidants against oxidative stress depends on the nature of oxidants. In the present...

artykuł

Isomer distribution of hydroxyoctadecadienoates (HODE) and hydroxyeicosatetraenoates (HETE) produced in the plasma oxidation mediated by peroxyl radical, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen

Aya Umeno, Mayuko Morita, Yasukazu Yoshida, Yuji Naito, więcej

Archives of Biochemistry and Biophysics > 2017 > 635 > C > 96-101

Free and ester forms of unsaturated fatty acids and cholesterol are oxidized in vivo by multiple oxidants to give diverse products. Some lipid oxidation is mediated by enzymes to selectively give specific products, while others proceed randomly to produce mixtures of many kinds of regioisomers and stereoisomers. The efficacy of antioxidants against lipid oxidation depends on the nature of the oxidants...

artykuł

Inhibition of plasma lipid oxidation induced by peroxyl radicals, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen by clinical drugs

Mayuko Morita, Yuji Naito, Toshikazu Yoshikawa, Etsuo Niki

Bioorganic & Medicinal Chemistry Letters > 2016 > 26 > 22 > 5411-5417

With increasing evidence showing the involvement of oxidative stress in the pathogenesis of various diseases, the effects of clinical drugs possessing antioxidant functions have received much attention. The unregulated oxidative modification of biological molecules leading to diseases is mediated by multiple oxidants including free radicals, peroxynitrite, hypochlorite, lipoxygenase, and singlet oxygen...

rozdział

A Gene Expression Profiling Approach to Study the Influence of Ultrafine Particles on Rat Lungs

Katsuhide Fujita, Yasuo Morimoto, Akira Ogami, Isamu Tanaka, więcej

Atmospheric and Biological Environmental Monitoring > Environmental Toxicity Monitoring and Assessment > 219-227

In recent years, industrial or commercial products incorporating nanomaterials have triggered concerns for human health. Manufactured nanomaterials are unstable and tend to form secondary particles by agglomeration. Little is known about the cytotoxicity induced by nano-sized secondary particles dispersed in aqueous solution. In the present study, we have attempted to disperse ultrafine nickel oxide...

artykuł

Oxidative stress and antioxidants: Distress or eustress?

Etsuo Niki

Archives of Biochemistry and Biophysics > 2016 > 595 > C > 19-24

There is a growing consensus that reactive oxygen species (ROS) are not just associated with various pathologies, but that they act as physiological redox signaling messenger with important regulatory functions. It is sometimes stated that “if ROS is a physiological signaling messenger, then removal of ROS by antioxidants such as vitamins E and C may not be good for human health.” However, it should...

artykuł

Rapid assessment of singlet oxygen-induced plasma lipid oxidation and its inhibition by antioxidants with diphenyl-1-pyrenylphosphine (DPPP)

Mayuko Morita, Yuji Naito, Toshikazu Yoshikawa, Etsuo Niki

Analytical and Bioanalytical Chemistry > 2016 > 408 > 1 > 265-270

Recent studies suggesting the involvement of singlet oxygen in the pathogenesis of multiple diseases have attracted renewed attention to lipid oxidation mediated by singlet oxygen. Although the rate constants for singlet oxygen quenching by antioxidants have been measured extensively, the inhibition of lipid oxidation mediated by singlet oxygen has received relatively less attention, partly because...

artykuł

Singlet-oxygen-derived products from linoleate activate Nrf2 signaling in skin cells

Yoko Akazawa-Ogawa, Mototada Shichiri, Keiko Nishio, Yasukazu Yoshida, więcej

Free Radical Biology and Medicine > 2015 > 79 > C > 164-175

Linoleates are required for normal mammalian health and development, but they are also prone to oxidation, resulting in biologically active metabolites such as hydroxyoctadecadienoic acids (HODEs). To investigate the biological activity of 9-EZ-HODE, 10-EZ-HODE, 12-ZE-HODE, and 13-ZE-HODE, the metabolites of singlet-oxygen-derived products from linoleates, we assessed adaptive cytoprotection in HaCaT...

artykuł

Biomarkers of lipid peroxidation in clinical material

Etsuo Niki

BBA - General Subjects > 2014 > 1840 > 2 > 809-817

Free radical-mediated lipid peroxidation has been implicated in a number of human diseases. Diverse methods have been developed and applied to measure lipid peroxidation products as potential biomarkers to assess oxidative stress status in vivo, discover early indication of disease, diagnose progression of disease, and evaluate the effectiveness of drugs and antioxidants for treatment of disease and...

artykuł

Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence

Etsuo Niki

Free Radical Biology and Medicine > 2014 > 66 > Complete > 3-12

Multiple reactive oxygen/nitrogen species induce oxidative stress. Mammals have evolved with an elaborate defense network against oxidative stress, in which multiple antioxidant compounds and enzymes with different functions exert their respective roles. Radical scavenging is one of the essential roles of antioxidants and vitamin E is the most abundant and important lipophilic radical-scavenging antioxidant...

artykuł

Oxidative stress is involved in fatigue induced by overnight deskwork as assessed by increase in plasma tocopherylhydroqinone and hydroxycholesterol

Mototada Shichiri, Nobuyoshi Harada, Noriko Ishida, Lilian Kaede Komaba, więcej

Biological Psychology > 2013 > 94 > 3 > 527-533

In this study, we examined the relationship between fatigue and plasma concentrations of antioxidants and lipid peroxidation products. Fourteen healthy volunteers performed overnight desk work for 18h then took a nap for 4h. Participants answered questionnaires of subjective symptoms of fatigue (QSSF) and completed a self-assessment of fatigue using a visual analog scale (VAS). At each test time,...

artykuł

Evaluation of biological activities of a groundnut (Apios americana Medik) extract containing a novel isoflavone

Mizuki Takashima, Kazuhiro Nara, Etsuo Niki, Yasukazu Yoshida, więcej

Food Chemistry > 2013 > 138 > 1 > 298-305

Groundnut (Apios americana Medik) contains a novel isoflavone, genistein-7-O-gentiobioside. In the present study, we examined the biological activities of an alcohol extract of groundnut containing genistein-7-O-gentiobioside as the main component. Although the groundnut extract by itself did not show antioxidative activity, it drove the antioxidative system in cells. Pretreatment of human breast...

artykuł

Chromium(III) oxide nanoparticles induced remarkable oxidative stress and apoptosis on culture cells

Masanori Horie, Keiko Nishio, Shigehisa Endoh, Haruhisa Kato, więcej

Environmental Toxicology > 28 > 2 > 61 - 75

Chromium(III) oxide (Cr₂O₃) is used for industrial applications such as catalysts and pigments. In the classical form, namely the fine particle, Cr₂O₃ is insoluble and chemically stable. It is classified as a low‐toxicity chromium compound. Recently, industrial application of nanoparticles (a new form composed of small particles with a diameter of ≤100 nm, in at least one dimension) has been increasing...

artykuł

Do antioxidants impair signaling by reactive oxygen species and lipid oxidation products?

Etsuo Niki

FEBS Letters > 2012 > 586 > 21 > 3767-3770

Oxidative modification of biologically essential molecules by reactive oxygen and nitrogen species (ROS/RNS) has been implicated in the pathogenesis of various diseases. At the same time, roles of ROS/RNS as physiological signaling messenger have been established. Lipid oxidation products also have two faces. It is argued that the radical scavenging antioxidants taken from diet or supplement may impair...

artykuł

Assessment of antioxidant capacity for scavenging free radicals in vitro: A rational basis and practical application

Mizuki Takashima, Masanori Horie, Mototada Shichiri, Yoshihisa Hagihara, więcej

Free Radical Biology and Medicine > 2012 > 52 > 7 > 1242-1252

With increasing evidence showing the involvement of oxidative stress induced by free radicals in the development of various diseases, the role of radical-scavenging antioxidants has received much attention. Although many randomized controlled clinical trials do not support the beneficial effects of indiscriminate supplementation of antioxidants, more recent studies suggest that antioxidants such as...

artykuł

α-Tocopheryl phosphate: Uptake, hydrolysis, and antioxidant action in cultured cells and mouse

Keiko Nishio, Noriko Ishida, Yoshiro Saito, Yoko Ogawa-Akazawa, więcej

Free Radical Biology and Medicine > 2011 > 50 > 12 > 1794-1800

α-Tocopheryl phosphate (α-TP), a water-soluble analogue of α-tocopherol, is found in humans, animals, and plants. α-TP is resistant to both acid and alkaline hydrolysis and may exert its own function in this form in vivo. In this study, the uptake, hydrolysis, and antioxidant action of α-TP were measured using α-TP with a deuterated methyl group, CD ₃ , at position 5 of the chroman ring (α-TP(CD3))...

artykuł

α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome

Mototada Shichiri, Yasukazu Yoshida, Noriko Ishida, Yoshihisa Hagihara, więcej

Free Radical Biology and Medicine > 2011 > 50 > 12 > 1801-1811

It is widely accepted that oxidative stress is involved in the pathogenesis of Down syndrome, but the effectiveness of antioxidant treatment remains inconclusive. We tested whether chronic administration of α-tocopherol ameliorates the cognitive deficits exhibited by Ts65Dn mice, a mouse model of Down syndrome. α-Tocopherol was administered to pregnant Ts65Dn females, from the day of conception throughout...

artykuł

Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function

Yoshiro Saito, Keiko Nishio, Yoko Ogawa Akazawa, Kazunori Yamanaka, więcej

Free Radical Biology and Medicine > 2010 > 49 > 10 > 1542-1549

Glutamate plays a critical role in pathological cell death within the nervous system. Vitamin E is known to protect cells from glutamate cytotoxicity, either by direct antioxidant action or by indirect nonantioxidant action. Further, α-tocotrienol (α-T3) has been reported to be more effective against glutamate-induced cytotoxicity than α-tocopherol (α-T). To shed more light on the function of vitamin...

artykuł

Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals

Yoko Ogawa Akazawa, Yoshiro Saito, Takao Hamakubo, Yoshinori Masuo, więcej

Neuroscience Letters > 2010 > 483 > 3 > 201-205

DJ-1, the causative gene of a familial form of Parkinson's disease (PD), has been reported undergo oxidation preferentially at the 106th cysteine residue (Cys-106) under oxidative stress. Recently, it has been found that the levels of oxidized DJ-1 in erythrocytes of unmedicated PD patients are markedly higher than those in medicated PD patients and healthy subjects. In the present study, we examined...

artykuł

Cellular responses by stable and uniform ultrafine titanium dioxide particles in culture-medium dispersions when secondary particle size was 100nm or less

Masanori Horie, Keiko Nishio, Katsuhide Fujita, Haruhisa Kato, więcej

Toxicology in Vitro > 2010 > 24 > 6 > 1629-1638

Even though there have been some investigations into cellular responses induced by ultrafine titanium dioxide (TiO ₂ ) in vitro, the relationship between cellular responses and secondary particle size is still not clear. In this study, a stable and uniform TiO ₂ -cell culture-medium dispersion was prepared, and cellular responses prompted by “ultrafine secondary particles” were examined...

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