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A multifunctional pH-sensitive superparamagnetic iron-oxide (SPIO) nanocomposite system was developed for simultaneous tumor magnetic resonance imaging (MRI) and therapy. Small-size SPIO nanoparticles were chemically bonded with antitumor drug doxorubicin (DOX) and biocompatible poly(ethylene glycol) (PEG) through pH-sensitive acylhydrazone linkages, resulting in the formation of SPIO nanocomposites...
A pH-responsive drug delivery system was developed through facile PEGylation of commercial aliphatic dendritic polyester Boltorn ® H40 (H40) by forming the acetal linkages. Benefiting from its amphiphilic structure, the star copolymer (H40-star-MPEG) with a hydrophobic H40 core and many hydrophilic poly(ethylene glycol) (MPEG) arms was able to self-assemble into stable micelles in aqueous...
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