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Nanomaterials with very low atomicity deserve consideration as potential pharmacological agents owing to their very small size and to their properties that can be precisely tuned with minor modifications to their size. Here, it is shown that silver clusters of three atoms (Ag3‐AQCs)—developed by an ad hoc method—augment chromatin accessibility. This effect only occurs during DNA replication. Coadministration...
Evidence of the significance of targeting chromatin compaction to increase the therapeutic index of chemotherapy is provided by Arturo López‐Quintela, Fernando Domínguez, and co‐workers in article number 1801317. Co‐administration of silver quantum clusters of three atoms, which increases chromatin accessibility, raises the efficacy of DNA‐binding drugs and the standard of care‐treatment of most human...
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