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Bone Regeneration
In article number 2200416, Hojeong Jeon, Justin J. Chung, and co‐workers fabricate complex coacervate of fucoidan and poly‐l‐lysine to prevent bone morphogenetic protein‐2 (BMP‐2) leakage from collagen sponges. The microencapsulation ability of the coacervate significantly enhances BMP‐2 bioactivity and provides protection against antagonist and proteolysis. Moreover, the BMP‐2...
Prompt and robust bone regeneration has been clinically achieved using supraphysiological doses of bone morphogenetic protein‐2 (BMP‐2) to overcome the short half‐life and rapid clearance. However, uncontrolled burst release of exogenous BMP‐2 causes severe complications such as heterotopic ossification and soft tissue inflammation. Therefore, numerous researches have focused on developing a new BMP‐2...
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