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Hypoxia sensing is the generic term for pO 2 -sensing in humans and other higher organisms. These cellular responses to pO 2 are largely controlled by enzymes that belong to the Fe(II) α-ketoglutarate (αKG) dependent dioxygenase superfamily, including the human enzyme called the factor inhibiting HIF (FIH-1), which couples O 2 -activation to the hydroxylation of the hypoxia...
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