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Bioactive factors were added into hydrogel scaffolds to overcome the shortcomings of their low cell affinity and poor bioactivity, as well as limited cell spreading ability for anchorage-dependent cells such as chondrocytes, MSCs, etc. But the direct addition of these bioactive factors may lead to high cost, short effective time and possible side effects etc. In this study, a flavonol glycosides named...
To maintain the long-time bioactivity of hydrogel scaffold and promote chondrogenesis, hyaluronic acid–icariin (HA–Ica) conjugate hydrogel was prepared. Firstly, methacrylic anhydride (MA)-modified icariin (MIca) and MA-modified hyaluronic acid (HAMA) were synthesized. MIca in aqueous solution formed nanoparticles, which were characterized by scanning electron microscopy and dynamic light scattering...
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