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CD4+CD25+ regulatory T (Treg) cells comprise a unique subset of T cells required for maintaining immune homeostasis. However, the molecular mechanisms associated with the functional variety of Treg cells are not fully delineated. In the present study, we demonstrate that ubiquitin‐specific protease (USP)4 physically interacted with interferon regulatory factor 8 (IRF8) function via a K48‐linked deubiquitinase,...
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