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•Introducing intravital microscopy imaging techniques for drug pharmacology. •Optical imaging enables in vivo measurements of pharmacokinetic. •Developing imaging modalities for single cell drug-target engagement measurements. •Measuring downstream pharmacodynamics response at the single cell level.
Introduction: Monochloramine (NH2Cl) is a reactive oxidant produced by the reaction of ammonia (NH3, generated by H. Pylori) with hypochlorous acid (HOCl, released by activated neutrophils). Targets of NH2Cl include thiol (S-H) groups on intracellular proteins such as metallothioneins. Oxidation of thiols releases Zn2+, an intracellular signal that prevents apoptosis by inhibiting conversion of procaspase-3...
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