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Genetic polyymorphisms that result in three amino acid changes in FcϵRI β chain (Ile 181 →Leu, Val 183 →Leu, and Glu 237 →Gly) have been identified as candidates that associate with allergic disorders such as atopy and asthma. To elucidate the biological significance of these polymorphisms in regulating the expression and function of FcϵRI, we generated four types of transfectants...
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