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The progression of 'nave' and 'memory' T-cells and the T-cell receptor Vβ (TCR Vβ) repertoire dynamics within the peripheral CD4 + T-cell compartment were studied in individuals following HIV seroconversion. Profound TCR Vβ repertoire perturbations were observed within the CD4 + T-cell pool in treatment-naive patients regardless of their levels of viremia during the first 6-8 months...
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