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Dioxins and dioxin-like chemicals cause a wide range of pathologies including carcinogenesis, immune dysfunction, and developmental/reproductive abnormalities. Most of these toxic effects are mediated by aryl hydrocarbon receptor (AhR; also called the dioxin receptor), a ligand-activated transcription factor. Constitutive activation of AhR via genetic manipulation causes development of cancers, inflammation...
Keywords:
MESANGIAL CELLS; PP60 V - S R C TYROSINE KINASE (V-SRC); Α-SMOOTH MUSCLE ACTIN; SERUM RESPONSE ELEMENT (SRE); EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK)
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