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Domains known as von Willebrand factor type D (VWD) are found in extracellular and cell‐surface proteins including von Willebrand factor, mucins, and various signaling molecules and receptors. Many VWD domains have a glycine‐aspartate‐proline‐histidine (GDPH) amino‐acid sequence motif, which is hydrolytically cleaved post‐translationally between the aspartate (Asp) and proline (Pro). The Fc IgG binding...