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Methods. Edematous pancreatitis was induced by the intraperitoneal injection of caerulein (50g/kg), seven times, at 1-h intervals, in male Wistar rats (caerulein pancreatitis). Inosine (100mg/kg) was administered 30min before or 1h after the first injection of caerulein. The effects of inosine on the severity of pancreatitis were assessed by serum amylase, pancreatic edema (wet/dry ratio), myeloperoxidase...
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