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In this paper, a very simple, easily-operated and universal platform is proposed for tumor marker detection. In this strategy, tumor marker-specific aptamer, which can quench the fluorescence of polyfluorene-based cationic conjugated polyelectrolytes (PFN+), are used as recognizing probes. Upon addition of tumor marker, the aptamer can be assembled into the tumor marker-aptamer complex, resulting...
This paper describes the poly(divinylbenzene) (PDVB) supported synthesis of quaternized hyperbranched macromolecules (QHMs) and its use as a highly selective, high-capacity mixed-mode anion-exchange (MAX) sorbent. In detail, the aminated PDVB support was firstly synthesized by copolymerization of divinylbenzene and 2-(diethylamino)ethyl methacrylate via Pickering emulsion polymerization. The QHMs...
Using photoelectrochemical (PEC) platform for ultrasensitive detection of sulfate-reducing bacteria (SRB) is a big challenge since sensor sensitive component can be damaged by corrosive metabolites. In this work, a novel bio-etching strategy for sensitizing PEC platform is developed to detect SRB. In the presence of bacterial metabolite (H2S), BiOCl platform can be bio-etched to form Bi2S3/BiOCl p-n...
Multiple miRNA detection is often limited by sample, time-consuming, and complicated procedures. To address such challenges, we present a relatively simple and amplification-free fluorescent strategy based on hybridization-initiated exonuclease resistance for simultaneous detection of multiple miRNAs in a single tube. Single-stranded linear DNA probes were designed with dual roles of capture and reporter...
Through introducing octakis (3-mercaptopropyl) octasilsesquioxane (POSS-SH) synthesized in our lab to the prepolymerization solution containing stearyl acrylate (SA), 1,6-hexanediol ethoxylate diacrylate (HEDA) in the existence of porogenic solvents (tetrahydrofuran, 1,4-butanediol and 1-propanol), a POSS-containing hybrid monolithic column was fabricated via photo-initiated thiol-acrylate polymerization...
A two-dimensional (2D) Ni based metal-organic framework (MOF) nanosheets were synthesized using a one-step solvent-thermal method. The as-prepared nanosheets were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), powder X-ray diffraction (XRD) and energy disperse spectroscopy (EDS) mapping. Ni-MOF nanosheet was first time found to used as a peroxidase mimetic...
Rapid, low-cost and efficient assays for penicillinase activity and inhibition are of vital importance for therapeutics and diagnostics of bacterial resistance to antibiotics. Herein we report a novel approach for on-line enzyme assays for penicillinase utilizing capillary electrophoresis-integrated immobilized enzyme reactors (CE-IMERs). The CE-IMERs are fabricated based on penicillinase-mediated...
In this study, a novel air-assisted liquid-liquid microextraction (AALLME) method was developed for the HPLC determination of bisphenols migration from disposable plastic lunch box to contacting water. The AALLME was carried out in commercially-available medical plastic syringes with low-density extraction solvent (n-octanol), and the reaction of NaHCO3 and HCl was introduced to simultaneously induce...
In this work, aqueous biphasic systems (ABSs) composed of ionic liquids (ILs) and deep eutectic solvents (DESs) were developed and utilized to efficiently extract DNA for the first time. Four kinds of ILs/DESs were mainly constituted by betaine/carboxylic acid and betaine/carbohydrates respectively. While another DES ([TBAB][PPG400]) was formed by polypropylene glycol 400 (PPG 400) and tetrabutylammonium...
A comprehensively comparative study of thiol-functionalized mesoporous silica and organic-inorganic hybrid monolithic column was reported, aiming at the separation and enrichment of inorganic arsenic. Thiol-functionalized mesoporous silica was synthesized based on the one-step co-condensation method. At the same time, a novel thiol-functionalized organic-inorganic hybrid monolithic column was synthesized...
Arsenic ion is a well-known harmful heavy element widely existing in the environment. Arsenic pollution occurring frequently has become increasing a serious worldwide threat to human health and the environment. The development of sensitive and reliable methods to detect As3+ in water is of great importance to biochemical research and monitoring applications. Herein, a label-free fluorescence sensing...
Excessive intake of kanamycin (KANA) can cause some serious drug-resistant diseases, so it is urgent to develop some accurate and rapid analytical methods for monitor KANA residues in foodstuffs with complex matrix. Recently, many ratiometric assays were reported to be capable of overcoming matrix interference. Herein, a ratiometric and homogeneous assay for KANA detection based on microchip electrophoresis...
In this paper, we introduced a new sensor for detecting sulfur mustard (SM) and its simulant through the functionalization of a rhodol chromophore with benzothiazole, followed by thionation of the spirolactam. The synthesized chemodosimeter (RHBT) exhibited an obvious green-yellow fluorescence enhancement and chromogenic change from colorless to fuchsia in the presence of SM and its simulant stimuli,...
A near infrared fluorescent probe YSP for sulfite was synthesized, in which a julolidine fused with a pyran-2-one was employed as the fluorophore and the vinyl activated by an indole salt as the receptor. The introduction of julolidine and indole salt strengthens the electron push-pull effect of the probe and allows it to absorb (597 nm) and emit (681 nm) in red wavelength region. The addition of...
In this paper, an amplified fluorescence polarization (FP) aptasensor based on magnetic nanoparticles @polydopamine (MNP@PDA) was innovatively developed for sensitive detection of recombinant human erythropoietin-alpha(rHuEPO-α). The amplified FP signal was due to the large mass of protein and MNP@PDA. And this assay can be utilized for target separation or recycling based on the magnetic property...
Recently, great efforts have been made to use biosensors for the early diagnosis of cancer. Specifically, using a biomarker to detect H2O2 in physiological conditions is of great significance for understanding the signal transduction pathways and achieving early cancer diagnosis. In this work, we report an innovative H2O2 sensor that was fabricated by trimetallic AuPtPd nanocomposites platform on...
In current study, an attapulgite nanoparticles-based hybrid monolith was prepared by crosslinking 3-trimethoxysilylpropyl methacrylate modified attapulgite nanoparticles with acrylamide and N, N′-methylenebisacrylamide. The crosslinking of attapulgite into the hybrid monolithic matrix has notable increased the column efficiency of adenosine comparing with the neat one without attapulgite. The resulting...
Trypsin, as one of important proteases, is specific for catalyzing the hydrolysis of peptide and ester bonds containing lysine and arginine residues at the C-terminus. The level of trypsin in biological fluids can serve as a reliable and specific diagnostic biomarker for pancreatic function and its pathological changes. Herein, we demonstrate the application of phosphorescent Cu NCs for trypsin detection...
In this paper, Fe3O4-doped nanoporous carbon (Fe3O4-NC) was synthesized through the carbonization of Fe-porous coordination polymer (Fe-PCP), which are also known as metal-organic framework (MOF), and fabricated into an electrochemical sensor for simultaneous analysis of diethylstilbestrol (DES) and 17β-estradiol (E2) in toner. Fe3O4-NC was characterized by scanning electron microscope (SEM), powder...
Intrinsically fluorescent polymer nanoparticles (F-PNPs) were synthetized from 2-hydroxy-5-methylisophthalaldehyde and melamine by solvothermal method. F-PNPs can emit strong yellow green fluorescence at 542 nm without the conjugation to any external fluorescent agent and surface modification. Owing to the abundant amino and hydroxyl groups on their surface, the F-PNPs possess multiple binding sites,...
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