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Background and Aims
Mothers against decapentaplegic homolog (SMAD) 7 is an antagonist of TGF‐β signaling. In the present investigation, we sought to determine the relevance of SMAD7 in liver carcinogenesis using in vitro and in vivo approaches.
Approach and Results
We found that SMAD7 is up‐regulated in a subset of human HCC samples with poor prognosis. Gene set enrichment analysis revealed that...
Inactivating mutations of axis inhibition protein 1 (AXIN1), a negative regulator of the Wnt/β‐Catenin cascade, are among the common genetic events in human hepatocellular carcinoma (HCC), affecting approximately 10% of cases. In the present manuscript, we sought to define the genetic crosstalk between Axin1 mutants and Wnt/β‐catenin as well as Notch signaling cascades along hepatocarcinogenesis....
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