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The Sonic Hedgehog (Shh) pathway affects cancer initiation, progression, and metastasis, but its role in papillary thyroid carcinoma (PTC) remains elusive. To characterize expression and clinical significance of Shh and the transcription factor Gli-1—the key elements of the Shh pathway in PTC tissues—we immunohistochemically examined Shh/Gli-1 expression in PTC tissues from 142 patients, along with...
The goal of the present study was to investigate whether p53 antibodies (Abs) could be a relevant marker for papillary thyroid carcinoma (PTC). Three types of enzyme-linked immunosorbent assay (ELISA) methods were developed for the detection of p53 Abs, including p53-ELISA, phage-SS-ELISA, and phage-SP-ELISA. A total of 304 patients, including 117 cases with thyroid adenoma and 187 PTC patients, were...
Single-nucleotide polymorphisms of rs965513 (9q22.33) and rs944289 (14q13.3) may be involved in the pathogenesis of papillary thyroid carcinoma (PTC). But, relevant genetic studies reported different results. The aim of this meta-analysis was to derive a more precise assessment of the association of rs965513/rs944289 polymorphism with PTC risk. Relevant studies were identified using PubMed, ISI Web...
Papillary thyroid carcinoma (PTC) is one of the most common tumors of the thyroid gland. The common risk factors of PTC include ionizing radiation, positive family history, and thyroid nodular disease. PTC was identified in Europeans by conducting a genome-wide association study, and a strong association signal with PTC was observed in rs944289 and NKX2-1 (located at the 14q13.3 locus), which was...
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